Calorie restriction in nonhuman primates: mechanisms of reduced morbidity and mortality

Calorie restriction and aging in nonhuman primates.

In the 75 years since the seminal observation of Clive McCay that restriction of calorie intake extends the lifespan of rats, a great deal has been learned about the effects of calorie restriction (CR; reduced intake of a nutritious diet) on aging in various short-lived animal models. Studies have demonstrated many beneficial effects of CR on health, the rate of aging, and longevity. Two prospe...

Calorie Restriction, Longevity and Cognitive Function

The Effects of Calorie Restriction in Depression and Potential Mechanisms

Depression, also called major depressive disorder, is a neuropsychiatric disorder jeopardizing an increasing number of the population worldwide. To date, a large number of studies have devoted great attention to this problematic condition and raised several hypotheses of depression. Based on these theories, many antidepressant drugs were developed for the treatment of depression. Yet, the depre...

Behavioral mechanisms underlying vocal communication in nonhuman primates

In the wild, nonhuman primate vocalizations signal the presence of different predators, provide information about the group's location and movement, facilitate friendly interactions, and lead to reconciliation between individuals who have recently exchanged aggression. Current research examines the mechanisms that underlie such communication. Playback experiments demonstrate that subjects treat...

securitization of mortality risks in life annuities

insurers have in the past few decades faced longevity risks - the risk that annuitants survive more than expected - and therefore need a new approach to manage this new risk. in this dissertation we survey methods that hedge longevity risks. these methods use securitization to manage risk, so using modern financial and insurance pricing models, especially wang transform and actuarial concepts, ...